I craft Wyvern Toxin in Baldur’s Gate 3 and I want to give you a clear, practical walkthrough based on long play sessions and community testing (as of 2025-06-01). I’ve noticed this poison changes fights when used smartly, but it’s not a magic button — there are limits and exceptions.
Where the recipe usually turns up 🧪
Reports and my runs point to the Underdark’s Myconid Colony as the most consistent place to check for the Wyvern Toxin recipe. Derryth Bonecloak, the dwarf trader there, often sells rare alchemy notes. I’ve bought it from her after a few rests; sometimes you need specific quest progress first. This doesn’t always work, and the shop inventory rotates.
Curious where else? Try looting high-level alchemy chests and searching assassin hideouts. Want a fast route? Act 3 vendors sometimes carry pre-made vials — pricey, yes (many players pay 500–800 gold), but reliable if you’re strapped for time!
Ingredients and where to find them (community averages)
| Ingredient | Primary Spot | Secondary Spot | Approx. Rate |
|---|---|---|---|
| Wyvern Poison Gland | Mountain Pass | Risen Road | ~70% |
| Serpent Venom | Swamp areas | Underdark | ~90% |
| Nightshade | Forests | Vendors | 100% |
| Sublimate of Wyvern Blood | Crafted / Alchemist vendors | — | varies |
These numbers come from player logs and my testing. Patch changes can alter drops (I checked community notes on 2025-06-01). If you see different values, the game might have changed—depends on your build and which enemies you find.
What you need to craft
- 1x Wyvern Poison Gland
- 2x Serpent Venom
- 1x Nightshade
- 1x Sublimate of Wyvern Blood (or equivalent)
- Empty vial + Alchemist’s Tools or an Alchemy Station
// Crafting formula (simple)
WyvernToxin = {
primary: [WyvernGland(1), SerpentVenom(2), Nightshade(1)],
catalyst: [Sublimate(1), BasicPoison(1)],
tools: AlchemyStation || AlchemistTools,
skill: Medicine || Nature (reports: around DC15)
}
How to brew — step by step ⚗️
Find an Alchemy Station (camp, Druid Grove, major settlements). Mix Serpent Venom with Nightshade first to build the base. Add the Wyvern Gland while the brew is active; expect a skill check (many players report Medicine or Nature around DC15). Failures can waste the rare gland — save before you try!
Honestly, the gland is the choke point. I’ve lost one to a bad roll and cursed loudly (between us, save often!).
Tip: If you don’t want to risk ingredients, buy a vial from high-level vendors or get them as quest rewards.
Combat uses and tactical notes ⚔️
Players use Wyvern Toxin mainly two ways: coat a weapon or throw it as an AoE vial. Reports vary about exact damage numbers by patch, but the toxin reliably inflicts poison damage and can cause the Poisoned condition on failed Con saves. Undead and constructs are often immune — check enemy resistances first.
Want a controversial take? Buying pre-made vials is for players who don’t want to play the game. Argue me down if you must — I’ve learned from grinding ingredients myself. Also, trapping choke points with poison feels cheap but it works.
Alternatives and extra methods
- Buy from Act 3 vendors (expensive).
- Complete assassination/poison quests for rewards.
- Loot high-level humanoids and alchemy shops (steal if your Sleight of Hand is high).
Oddly enough, sometimes trading or merchants tied to story beats stock what you need after a specific date or choice (I noticed this after a playthrough on 2025-05-12).
Final practical advice
I’ve found the best routine: farm a wyvern or two near Mountain Pass, gather excess Serpent Venom while exploring swamps, keep Nightshade on hand, then craft at camp. Save before brewing — seriously.
One counterintuitive insight: using smaller, repeated applications (weapon coating) can outvalue one big AoE in fights where failing a save ruins your setup. Try both and see what fits your party.
Go test this now — but remember, some things change with patches, and there are exceptions. Happy hunting!
